| Zugriffsnummer | 17037 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Ion chromatographic precision measurement procedure for electrolytes in human serum: validation with the aid of primary measurement procedures |
| Autor(in); Institution |
Röhker, Karin; 3.1, Metrologie in der Chemie, PTB-Braunschweig
Rienitz, Olaf; 3.1, Metrologie in der Chemie, PTB-Braunschweig
Schiel, Detlef; 3.1, Metrologie in der Chemie, PTB-Braunschweig
|
| Quelle/Jahr | Accreditation and Quality Assurance: 9 (2004), 11/12, 671 - 677 |
| ISSN | 0949-1775 (PRINT) ; 1432-0517 (ONLINE) |
| DOI | |
| Verlag | Heidelberg [u.a.]: Springer |
| Freie Schlagworte | Ion chromatography ; Traceability ; Uncertainty budget ; Clinical chemistry ; Electrolytes |
| Zusammenfassung | In order to make analytical measurement results traceable to the SI units in the field of clinical chemistry, an ion chromatographic (IC) measurement procedure has been developed which allows the amount of substance of the four so-called electrolytes Na, K, Mg and Ca as well as that of Li to be determined efficiently in human serum and with high accuracy. The IC measurement procedure was validated using primary measurement procedures confirmed by international comparison measurements and is proposed for use as a transfer standard when comparing measurements with clinical reference laboratories. The solutions used for calibration were gravimetrically prepared from pure substances (salts). Their chemical compositions had been iteratively fitted to those of the samples. The serum samples were mineralized by microwave-assisted digestion. The following relative expanded uncertainties for the average elemental contents were obtained: Li 0.4%, Na 0.14%, K 0.6%, Mg 0.8% and Ca 0.4%. |
Zitierung
Röhker, K., Rienitz, O., & Schiel, D. (2004). Ion chromatographic precision measurement procedure for electrolytes in human serum: validation with the aid of primary measurement procedures. Accreditation and Quality Assurance, 9(11/12), 671–677. https://doi.org/10.1007/s00769-004-0887-x