| Zugriffsnummer | 13963 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Magnetic marker monitoring of disintegrating capsules |
| Autor(in); Institution |
Weitschies, Werner; Ernst-Moritz-Arndt-Univ. Greifswald, GERMANY
Karaus, Michael; Institut für Diagnostikforschung, FU Berlin, GERMANY
Cordini, Dino; Institut für Diagnostikforschung, FU Berlin, GERMANY
Trahms, Lutz; 8.21, Bioelektrizität und -magnetismus, PTB-Berlin
Breitkreuz, Jörg; Institut für Diagnostikforschung, FU Berlin, GERMANY
Semmler, Wolfhard; Institut für Diagnostikforschung, FU Berlin, GERMANY
|
| Quelle/Jahr | European journal of pharmaceutical sciences: 13 (2001), 4, 411 - 416 |
| ISSN | 0928-0987 (PRINT) ; 0928-0987 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Magnetische Marker in der Gastroenterologie |
| Zusammenfassung | Magnetic marker monitoring was studied for its applicability to investigate the in vivo fate and behavior of disintegrating magnetically marked dosage forms. As a model, hard gelantin capsules were filled with an effervescent mixture of lactose, ascorbic acid and sodium hydrogen carbonate containing 1.3 mg black iron oxide as a magnetic label. The accuracy of the localization procedure whilst calculating all parameters of the dipole in one fitting procedure was checked in phantom experiments where the capsules were moved in well-defined paths with respect to the measurement device. The calculated position coordinates of the capsules deviated between less thean 2 mm up to 8 mm from the expected position values depending on the distance between the sensor area and the capsule's path. Further experiments on the in vitro disintegration of the capsules showed that the value of the magic moment of the capsules can serve as a measure for their disintegration behavior. In vivo monitoring of the capsules was performed in eight experiments where a healthy volunteer swallowed each time one of the capsules. It was found that the in vivo disintegration behavior of the capsules corresponds well to their disintegration observed in water of about 37°C. |
