| Zugriffsnummer | 13679 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Determining changes in NIR absorption using a layered model of the human head |
| Autor(in); Institution |
Steinbrink, Jens; 8.12, Biomedizinische Optik und NMR-Messtechnik, PTB-Berlin
Wabnitz, Heidrun; 8.12, Biomedizinische Optik und NMR-Messtechnik, PTB-Berlin
Obrig, Helmuth; Neurologische Klinik, Charité, Humboldt-Universität Berlin, GERMANY
Villringer, Arno; Neurologische Klinik, Charité, Humboldt-Universität Berlin, GERMANY
Rinneberg, Herbert; 8, Medizinphysik und metrologische Informationstechnik, PTB-Berlin
|
| Quelle/Jahr | Physics in Medicine and Biology: 46 (2001), 3, 879 - 896 |
| ISSN | 0031-9155 |
| DOI | |
| Verlag | Bristol: IOP |
| Klassifikationscode | PACS: 87.50.W- ; PACS: 02.50.Ng ; PACS: 87.56.Da ; PACS: 87.64.K- |
| Freie Schlagworte | near-infrared spectroscopy ; tissue spectroscopy ; time-resolved diffuse reflectance |
| Zusammenfassung | A theoretical approach is presented to determine absorption changes in different compartments of a layered structure from distributions of times of flight of photons. In addition resulting changes in spatial profiles of time-integrated intensity and mean time of flight are calculated. The capability of a single-distance, time-domain method to determine absorption changes with depth resolution is tested on a layered phantom. We apply this method to in vivo measurements on the human head (motor stimulation, Valsalva manoeuvre) and introduce a small-sized time-domain experimental set-up suitable for bed-side monitoring. |
