| Zugriffsnummer | 12950 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | The effectiveness of monoenergetic neutrons at 565 keV in producing dicentrics in human lymphocytes at low doses |
| Autor(in); Institution |
Schmid, Ernst; Forschungszentrum für Gesundheit und Umwelt, Institut für Radiobiologie, Neuherberg, GERMANY
Regulla, Dieter; Forschungszentrum für Gesundheit und Umwelt, Institut für Strahlenschutz, Neuherberg, GERMANY
Guldbakke, Sigmund; 6.41, Neutronenmetrologie, PTB-Braunschweig
Schlegel, Dietrich; 6.41, Neutronenmetrologie, PTB-Braunschweig
Bauchinger, Manfred; Forschungszentrum für Gesundheit und Umwelt, Institut für Radiobiologie, Neuherberg, GERMANY
|
| Quelle/Jahr | Radiation Research: 154 (2000), 307 - 312 |
| ISSN | 0033-7587 |
| Verlag | Great Falls, Va.: Radiation Research Society |
| Freie Schlagworte | RBE of 565 keV neutrons |
| Zusammenfassung | The induction of dicentrics in human lymphocytes from one individual irradiated in vitro to monoenergetic neutrons at 565 keV was examined to provide additional data for an improved evaluation of neutrons in radioprotection with respect to radiation risk. The resulting linear dose-response relationship obtained (0.813 ± 0.052 dicentrics per cell per Gy) over the dose range of 0.0213 - 0.167 Gy is consistent with published results obtained for irradiation with neutrons of different sources and spectra at energies lower than 1000 keV. Comparing this value to previously published "average" dose response curves obtained by different laboratories for 60Co γ-rays and orthovoltage X-rays, resulted in maximum RBEs (RBEm) of about 37 ± 8 and 16 ± 4, respectively. However, when our neutron data was matched to low-LET dose responses that were constructed several years earlier for lymphocytes from the same individual, higher values of RBEm resulted: 76.0 ± 29.5 for 60Co γ-rays, 54.2 ± 18.4 for 137Cs γ-rays; differentially filtered 220 kV X-rays produced RBEm of between 20.3 ± 2.0 or 37.0 ± 7.1. The results highlight the dependence of RBEm on the choice of low LET reference radiation, and raise the possibility that differential individual response to low LET radiations may need to be examined more fully in this context. |
