| Zugriffsnummer | 11552 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Environmental radiation does not enhance the tolerance of yeast cells to acute radiation exposure |
| Autor(in); Institution |
Frankenberg, D.; Universität Göttingen, Klinische Strahlenbiologie und Klinische Strahlenphysik, Göttingen, GERMANY
Helmstädter, Klaus; 6.51, Personendosimetrie, PTB-Braunschweig
Böhm, Jürgen; 6.5, Strahlenschutzmetrologie, PTB-Braunschweig
Pessara, Wilfried; 6.5, Strahlenschutzmetrologie, PTB-Braunschweig
Frankenberg-Schwager, M.; Universität Göttingen, Klinische Strahlenbiologie und Klinische Strahlenphysik, GERMANY
|
| Quelle/Jahr | Fundamentals for the assessment of risks from environmental radiation : [proceedings of the NATO Advanced Research Workshop]:(1999), 135 - 140 |
| Schriftenreihe | NATO science series, series 2, Environmental security: 55 |
| Herausgeber(in) |
Baumstark-Khan, Christa
|
| ISBN | 0-7923-5668-3 |
| Verlag | Dordrecht [u.a.]: Kluwer |
| Konferenzangaben | Advanced Research Workshop on Fundamentals for the Assessment of Risks from Environmental Radiation, Brno, 06-10, October, 1997, Czech Republic |
| Freie Schlagworte | underground laboratory ; double-strand breaks ; repair ; dosimetry |
| Zusammenfassung | The aim of the investigations was to clarify whether cells adapted to the normal background radiation show enhanced resistance to the damaging effects of ionizing radiation. The underground laboratory for dosimetry and spectrometry (UDO) of the Physikalisch-Technische Bundesanstalt (PTB) at a depth of 925 m allowed to grow cells at a dose rate of 2.2 nSv/h compared with about 110 nSv/h of the normal background radiation. The yeast mutant rad54-3 which is temperature conditional for the repair of DANN double-strand breaks (dsb) was cultivated at 2.2 and 110 nSv/h, respectively, and irradiated in UDO using electrons (90Sr/90Y). This mutant rad54-3 allows to determine separately induction and repair of dsb, solely by cultivating irradiated cells at 36 °C (no dsb repair) or at 23 °C (with dsb repair). The results show that the normal background radiation does not adapt yeast cells for reduced initial dsb and elevated repair of dsb. |
Zitierung
Frankenberg, D., Helmstädter, K., Böhm, J., Pessara, W., & Frankenberg-Schwager, M. (1999). Environmental radiation does not enhance the tolerance of yeast cells to acute radiation exposure. Advanced Research Workshop on Fundamentals for the Assessment of Risks from Environmental Radiation, Brno, 06-10, October, 1997, Czech Republic.