| Zugriffsnummer | 11397 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Development of a time-domain optical mammograph and first in vivo applications |
| Autor(in); Institution |
Grosenick, Dirk; 8.12, Biomedizinische Optik und NMR-Messtechnik, PTB-Berlin
Wabnitz, Heidrun; 8.12, Biomedizinische Optik und NMR-Messtechnik, PTB-Berlin
Rinneberg, Herbert; 8, Medizinphysik und metrologische Informationstechnik, PTB-Berlin
Moesta, K. Thomas; Robert-Rössle-Klinik, Charité, Humboldt-Universität, Berlin, GERMANY
Schlag, Peter M.; Robert-Rössle-Klinik, Charité, Humboldt-Universität, Berlin, GERMANY
|
| Quelle/Jahr | Applied Optics: 38 (1999), 13, 2927 - 2943 |
| ISSN | 0003-6935 |
| DOI | |
| Verlag | Washington, DC: Soc. |
| Klassifikationscode | OCIS: 170.3660 ; OCIS: 170.5270 ; OCIS: 170.6920 |
| Freie Schlagworte | optical mammography ; time-resolved imaging ; light propagation in tissues |
| Zusammenfassung | We have developed a laser pulse mammograph capable of recording optical mammograms within about 3 min by measuring time-resolved transmittance at each of typically 1500 scan positions, 2.5 mm apart. As a first application two patients with tumors were investigated successfully. From measured distributions of times of flight of photons corrected for edge effects we derived (i) characteristic quantities, such as photon counts in selected time windows, to generate optical mammograms, (ii) effective transport scattering and absorption coefficients of breast tissue at each scan position assuming the breast to be homogeneous, (iii) optical properties of a selected tumor applying the theory of diffraction of photon density waves by a spherical inhomogeneity. Mammograms recorded at different lateral offsets between source and detector fiber were used to estimate the depth of inhomogeneities. |
