| Zugriffsnummer | 11352 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Magnetographic evaluation of a genetically characterized family with hypertrophic cardiomyopathy |
| Autor(in); Institution |
Selbig, D.; Forschungszentrum Jülich, GERMANY
Bode, M.; Forschungszentrum Jülich, GERMANY
Soltner, H.; Forschungszentrum Jülich, GERMANY
Ziegert, K.; Dep. of Cardiology RWTH Aachen, GERMANY
Halling, H.; Forschungszentrum Jülich, GERMANY
Bousack, H.; Forschungszentrum Jülich, GERMANY
Trahms, Lutz; 8.21, Bioelektrizität und -magnetismus, PTB-Berlin
Stellbrink, C.; Dep. of Cardiology RWTH Aachen, GERMANY
|
| Quelle/Jahr | Recent advances in biomagnetism : proceedings of the 11th International Conference on Biomagnetism:(1999), 1063 - 1064 |
| Herausgeber(in) |
Yoshimoto, Takashi
|
| Verlag | Sendai: Tohoku University |
| Konferenzangaben | 11th International Conference on Biomagnetism, Sendai, 28, August - 02, September, 1998, Japan |
| Zusammenfassung | Hypertrophic cardiomyopathy (HCM) is a primary heart muscle disease characterized by left ventricular hypertrophy and myofibrillar disarray. Sudden cardiac death (SCD) is frequently the first manifestation of the disease in apparently healthy young individuals. The majority of these individuals who survive an episode of SCD due to ventricular tachycardia or fibrillation will fulfill the conventional diagnostic criteria. Occasionally the echocardiographic features can not exactly identify the current diagnostic criteria or there are existing only minor ECG abnormalities. In the recent years a range of main mutations in four different contractile protein genes - β-myosin heavy chain, cardiac troponin T, cardiac α-tropomyosin and myosin-binding protein C - have been shown to cause HCM as a hereditary disorder. However, the identification of the mutation is at present a research procedure and not available as a routine clinical service. Therefore an identification of SCD survivors with borderline clinical criterias and of apparently healthy gene carriers in HCM families is a substantial task. The aim of our study was to estimate the diagnostic value of the HTc-MCG in identifying patients and gene carriers in a genetically characterized HCM family. |
Zitierung
Selbig, D., Bode, M., Soltner, H., Ziegert, K., Halling, H., Bousack, H., Trahms, L., & Stellbrink, C. (1999). Magnetographic evaluation of a genetically characterized family with hypertrophic cardiomyopathy. 11th International Conference on Biomagnetism, Sendai, 28, August - 02, September, 1998, Japan.