| Zugriffsnummer | 10182 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Dynamic NMR spectroscopy of hyperpolarized 129Xe in human brain analyzed by an uptake model |
| Autor(in); Institution |
Kilian, Wolfgang; 8.12, Biomedizinische Optik und NMR-Messtechnik, PTB-Berlin
Seifert, Frank; 8.12, Biomedizinische Optik und NMR-Messtechnik, PTB-Berlin
Rinneberg, Herbert; 8, Medizinphysik und metrologische Informationstechnik, PTB-Berlin
|
| Quelle/Jahr | Magnetic Resonance in Medicine: 51 (2004), 4, 843 - 847 |
| ISSN | 0740-3194 |
| DOI | |
| Verlag | New York: Wiley |
| Freie Schlagworte | Hyperpolarisierte Edelgase ; Xenon ; MR-Spektroskopie |
| Zusammenfassung | Hyperpolarized 129Xe (HpXe) NMR not only holds promise for functional lung imaging but for measurements of tissue perfusion as well. To investigate human brain perfusion, several time-series of 129Xe MR spectra were recorded from one healthy volunteer after HpXe inhalation. The time-dependent amplitudes of the MR spectra were analyzed by using a compartment model for xenon uptake modified to account for the loss of 129Xe polarization due to RF-excitation and for the breath-hold technique used in the experiments. This analysis suggests that the resonances detected at 196.5±1ppm and 193±1ppm originate from HpXe dissolved in grey and white matter,respectively, and that T1 relaxation times of HpXe are different in grey and white matter (T1g ) T1w). |
