| Zugriffsnummer | 10134 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Track structure simulation: A basic tool for molecular radiation biology and nanodosimetry |
| Autor(in); Institution |
Großwendt, Bernd; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
|
| Quelle/Jahr | Computing radiation dosimetry - CRD 2002 : workshop proceedings, Sacavém, Portugal, 22 - 23 June 2002:(2004), 161 - 178 |
| Herausgeber(in) |
Nuclear Energy Agency, OECD
|
| ISBN | 92-64-10823-8 |
| Berichtsnummer | NEA 4311 |
| Verlag | Paris: OECD Publications |
| Konferenzangaben | Workshop on Computing Radiation Dosimetry, Sacavém, Lissabon, 22-23, June, 2002, Portugal |
| Freie Schlagworte | Track structure of electrons ; Photons and light ions ; Structural microdosimetry ; Radiation-induced biological effects |
| Zusammenfassung | As is well known from radiation chemistry, the kinetics of radiation-induced systems strongly depends on the distribution of atomic or molecular species produced by primary interactions of ionizing radiation in matter or, and this is the same, on the particle track structure. Far-reaching consequences can also be expected, therefore, if biological systems are exposed to ionizing radiation, the more so as the radiation-sensitive parts of such systems are located inside highly structured cells. In consequence, the knowledge of track structure is one of the prerequisites for a deeper understanding of radiation-induced effects in radiation chemistry and radiation biology. After a short overview of basic physical aspects of the track structure of electrons, photons and light ions (protons, α-particles, carbon ions) in liquid water, a few consequences of their radiation interaction in nanometric volumes are discussed, which can be related to radiation damage within segments of the DNA molecule and to bio-effect cross sections of mammalian cells for ionizing particles. Here, special emphasis is laid on the stochastic nature of ionization cluster-size formation in liquid water and on its potential application in nanodosimetric measurements. |
